Personally I think people will have to wait for L5 communities or the Mars colony before they find total freedom (and even then I have my doubts). Not trying to douse the passion for freedom, just trying to be realistic....
Thanks, StPeter, for injecting a dose of realism here. I think we sometimes get so excited about the potential of what we're trying to accomplish here that we omit crucial aspects of what history teaches us about human nature and society. I'm reasonably optimistic about our chances of winning a couple of states over to the liberty agenda in time, but I do not believe, as some apparently do, that the other states will simply fall over like dominoes in our wake.
Consider the United States of America itself. All the world envies our power and prosperity, yet, how many nations out there are really trying to emulate our founding political ideals? Indeed, most countries criticize us whenever they're presented with an opportunity to do so. Why are the other nations of the world not falling like dominoes in the wake of our example?
By the same token, I don't believe that the other US states will simply conceed defeat and surrender the political battleground to us. It's more likely that they'll find ways to tap our prosperity instead of recreating it for themselves. That's the path of least resistance, and history bears out that it's the path most often traveled by individuals and nations.
I've joked about the federal government putting us all on a reservation somewhere and acting like we don't exist, but perhaps that's not so far-fetched after all. If we succeed in holding forth for liberty in one or two states of the Union, and others flock there to benefit from it, our sheer numbers and volume may convince the feds to grant us the opt-outs that Jason has talked about. In this aspect, we'd be very much like another country (or a commonwealth), but still remain a member of the United States.
Full secession is certainly not unconstitutional, but it is highly unlikely (at least in the near future). Alaska may be the only exception to this; it certainly has the most potential for it.